ABL1 T315I Mutation Detection Kit

The AmoyDx ABL1 T315I Mutation Detection Kit is a sensitive and selective assay for the detection of the T315I mutation in the ABL1 gene.

Studies show that Gleevec inhibits the growth of ABL1 mutation-positive cells but has little effect over cells with normal ABL1 gene. The gene mutation and/or amplification will cause the drug esistance of CML (Chronic myelogenous (or myeloid) leukemia) patients to Gleevec. Undoubtedly, the T315I mutation is the most important mutations of BCR-ABL1 in TKI drug resistance. Thus, knowing the mutation status of BCR-ABL1 for CML patients will determine if the patients are resistant to Gleevec or not.

Intended Use: For research purpose use only. To detect the ABL1 T315I mutation in DNA samples.

Technological Principles: The ABL1 T315I mutation detection kit employs a real-time PCR format combined with patented technology - “mutation specific amplification technology” - to detect mutations in DNA samples. The method is much more specific and sensitive than alternative technologies such as DNA sequencing.

AmoyDx ABL1 T315I Mutation Detection kits are available in different sizes:

Product Name Size (test/Kit) Storage Cat. No.
ABL1 T315I Mutation Detection Kit 24t -20 ° C ADx-AB01
ABL1 T315I Mutation Detection Kit 48t -20 ° C ADx-AB02
ABL1 T315I Mutation Detection Kit 96t -20 ° C ADx-AB03