Mouse anti- Human B2M monoclonal antibody

Product Type: Monoclonal antibodies
Product Name: Mouse anti- Human B2M monoclonal antibody
Size: 100ug
Code: CSB-MA057862A0m
Immunogen: Recombinant human B2M protein
Raised in: mouse
Species Reactivity:
Spectificity: specific for native and denatured forms
Tested Applications: ELISA, WB, and other possible application
Relevance: Beta 2 Microglobulin non-covalently associates with the 44 kDa alpha chain to form the HLA Class I antigen complex. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, mon
Clonality: monoclonal
Isotype: IgG1
Purity: >95% by Caprylic Acid Ammonium Sulfate Precipitation purified
Conjugate: Non-conjugated
Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: liquid
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles
References: [1] Sharifiaghdas F, Kashi AH, Eshratkhah R.Evaluating Percutaneous Nephrolithotomy-Induced Kidney Damage by Measuring Urinary Concentrations of ?2-Microglobulin. Urol J. 2011 Fall;8(4):277-82. [2] Johnston O, Cassidy H, OConnell S, ORiordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. Identification of ?2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 2011 Aug;5(7-8):422-31. doi: 10.1002/prca.201000160. Epub 2011 Jul 13. [3] Stefanovi? V, Djukanovi? L, Cukuranovi? R, Bukvi? D, Ležai? V, Mari? I, Ogrizovic SS, Jovanovi? I, Vlahovic P, Peši? I, Djordjevi? V. Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease. Ren Fail.2011;33(2):176-83. [4] Kals J, Zagura M, Serg M, Kampus P, Zilmer K, Unt E, Lieberg J, Eha J, Peetsalu A, Zilmer M.?2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients. Scand J Clin Lab Invest. 2011 Jul; 71(4):257-63. [5] Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury.Nat Biotechnol. 2010 May;28(5):463-9.[1] Sharifiaghdas F, Kashi AH, Eshratkhah R.Evaluating Percutaneous Nephrolithotomy-Induced Kidney Damage by Measuring Urinary Concentrations of ?2-Microglobulin. Urol J. 2011 Fall;8(4):277-82. [2] Johnston O, Cassidy H, OConnell S, ORiordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. Identification of ?2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 2011 Aug;5(7-8):422-31. doi: 10.1002/prca.201000160. Epub 2011 Jul 13. [3] Stefanovi? V, Djukanovi? L, Cukuranovi? R, Bukvi? D, Ležai? V, Mari? I, Ogrizovic SS, Jovanovi? I, Vlahovic P, Peši? I, Djordjevi? V. Beta2-microglobulin and alpha1-microglobulin as markers of Balkan endemic nephropathy, a worldwide disease. Ren Fail.2011;33(2):176-83. [4] Kals J, Zagura M, Serg M, Kampus P, Zilmer K, Unt E, Lieberg J, Eha J, Peetsalu A, Zilmer M.?2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients. Scand J Clin Lab Invest. 2011 Jul; 71(4):257-63. [5] Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury.Nat Biotechnol. 2010 May;28(5):463-9. [6] Yamamoto-Furusho JK, Camacho-Escobedo J, Téllez-Avila F, Barreto R. Serum levels of beta2 microglobulin and ultrasensitive c-reactive protein as markers of histological activity in ulcerative colitis.Gac Med Mex. 2010 Jan-Feb;146(1):31-5. [7] Kim HA, Jeon JY, Yoon JM, Suh CH. Beta 2-microglobulin can be a disease activity marker in systemic lupus erythematosus.Am J Med Sci. 2010 Apr;339(4):337-40. [8] Kawai K, Kawashima S, Miyazaki T, Tajiri E, Mori M, Kitazaki K, Shirotani T, Inatome T, Yamabe H, Hirata K, Yokoyama M. J Cardiol. Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients. 2010 Jan; 55(1):99-107. [9] Bien E, Balcerska A. Serum soluble interleukin-2 receptor, beta2-microglobulin, lactate dehydrogenase and erythrocyte sedimentation rate in children with Hodgkins lymphoma.Scand J Immunol. 2009 Nov; 70(5):490-500. [10] Gentile M, Cutrona G, Neri A, Molica S, Ferrarini M, Morabito F. Predictive value of beta2-microglobulin (beta2-m) levels in chronic lymphocytic leukemia since Binet A stages.Haematologica. 2009 Jun; 94(6):887-8. [11] Delgado J, Pratt G, Phillips N, Briones J, Fegan C, Nomdedeu J, Pepper C, Aventin A, Ayats R, Brunet S, Martino R, Valcarcel D, Milligan D, Sierra J. Beta2-microglobulin is a better predictor of treatment-free survival in patients with chronic lymphocytic leukaemia if adjusted according to glomerular filtration rate.Br J Haematol. 2009 Jun;145(6):801-5. [12] Shi C, Zhu Y, Su Y, Chung LW, Cheng T. Beta2-microglobulin: emerging as a promising cancer therapeutic target.Drug Discov Today. 2009 Jan;14(1-2):25-30. [13] Bossard C, Bézieau S, Matysiak-Budnik T, Volteau C, Laboisse CL, Jotereau F, Mosnier JF. HLA-E/?2 microglobulin over-expression in colorectal cancer is associated with recruitment of inhibitory immune cells and tumor progression.Int J Cancer.2011 Sep 22. doi: 10.1002/ijc.26453. [14] Grenier J, Serrou B, Suquet P, Pujol H. Comparison of the variations in the levels of beta2-microglobulin and carcino-embryonic antigen in the breast cancer and malignant melanoma. Pathol Biol (Paris). 1978 Sep;26(6):371-2. [15] Kin K, Sakurabayashi I, Kawai T. Beta2-microglobulin levels of serum and ascites in malignant diseases.Gann. 1977 Aug;68(4):427-34. [16] Ripoll E, Arribas I, Relea P, Varela L, Villa LF, Revilla M, Rico H. Beta-2-microglobulin in diseases with high bone remodeling. Calcif Tissue Int. 1995 Oct;57(4):272-6. [17] Steinhoff J, Feddersen A, Wood WG, Hoyer J, Bein G, Wiedemann G, Fricke L, Sack K. Beta2-microglobulinuria as an early sign of cytomegalovirus infection following renal transplantation.Transpl Int. 1992;5 Suppl 1:S300-2. [18] Caruso L, Trischitta C, Russello M, Bertino G, Onorante A, Rapisarda S, Patania S, Tropeano L. High beta2 microglobulin serum levels in human immunodeficiency virus infected intravenous drug addicts. J Chemother. 1989 Jul;1(4 Suppl):1077-8. [19] Kraj M, Maj S, Pog?ód R, Rostkowska J. Clinical usefulness of serum beta2-microglobulin determination in patients with multiple myeloma. Acta Haematol Pol. 1989 Jul-Dec;20(2):140-51. [20] Wilczek H. Is beta 2-microglobulin a marker of bone remodeling in Pagets disease of bone. Cas Lek Cesk. 1997 Dec 3;136(23):730-2.
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