Mouse anti- Human Cystatin C monoclonal Antibody

Product Type: Monoclonal antibodies
Product Name: Mouse anti- Human Cystatin C monoclonal Antibody
Size: 100ug
Code: CSB-MA061901A0m
Immunogen: Recombinant Human Cystatin C protein
Raised in: mouse
Species Reactivity: Human
Spectificity: specific for native and denatured forms
Tested Applications: ELISA, WB, and other possible application
Relevance: Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary general
Clonality: monoclonal
Isotype: IgG2b
Purity: >95% by Caprylic Acid Ammonium Sulfate Precipitation purified
Conjugate: Non-conjugated
Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form: liquid
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles
References: [1] Vupputuri S, Robinson B, Brannon E, Owen-Smith A.PS2-40: Cystatin C Heralds Early Chronic Kidney Disease Especially in Diabetes (CHECKED): Results from a Pilot Study. Clin Med Res. 2011 Nov;9(3-4):161-2. [2] Hojs R, Bevc S, Ekart R, Gorenjak M, Puklavec L.Serum cystatin C-based equation compared to serum creatinine-based equations for estimation of glomerular filtration rate in patients with chronic kidney disease. Clin Nephrol. 2008 Jul;70(1):10-7. [3] Borges RL, Hirota AH, Quinto BM, Ribeiro AB, Zanella MT, Batista MC.Is cystatin C a useful marker in the detection of diabetic kidney disease? Nephron Clin Pract. 2010;114(2):c127-34. Epub 2009 Nov 3. [4] Spanaus KS, Kollerits B, Ritz E, Hersberger M, Kronenberg F, von Eckardstein A; Mild and Moderate Kidney Disease (MMKD) Study Group.Serum creatinine, cystatin C, and beta-trace protein in diagnostic staging and predicting progression of primary nondiabetic chronic kidney disease. Clin Chem. 2010 May;56(5):740-9. Epub 2010 Mar 11. [5] Shlipak MG, Katz R, Kestenbaum B, Fried LF, Newman AB, Siscovick DS, Stevens L, Sarnak MJ.Rate of kidney function decline in older adults: a comparison using creatinine and cystatin C. Am J Nephrol. 2009;30(3):171-8. Epub 2009 Apr 7. [6] Pucci L, Triscornia S, Lucchesi D, Fotino C, Pellegrini G, Pardini E, Miccoli R, Del Prato S, Penno G. Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients. Clin Chem. 2007 Mar;53(3):480-8. Epub 2007 Jan 26. [7] Yang YS, Peng CH, Lin CK, Wang CP, Huang CN.Use of serum cystatin C to detect early decline of glomerular filtration rate in type 2 diabetes. Intern Med. 2007;46(12):801-6. Epub 2007 Jun 15. [8] Hojs R, Bevc S, Ekart R, Gorenjak M, Puklavec L.Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function.. Nephrol Dial Transplant. 2006 Jul;21(7):1855-62. Epub 2006 Mar 8. [9] Hannemann A, Friedrich N, Dittmann K, Spielhagen C, Wallaschofski H, V Lzke H, Rettig R, Endlich K, Lendeckel U, Stracke S, Nauck M.Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate. Clin Chem Lab Med. 2011 Nov 14. [10] Mussap M, Dalla Vestra M, Fioretto P, Saller A, Varagnolo M, Nosadini R, Plebani M.Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients. Kidney Int. 2002 Apr;61(4):1453-61. [11] Muntner P, Vupputuri S, Coresh J, Uribarri J, Fox CS.Metabolic abnormalities are present in adults with elevated serum cystatin C. Kidney Int. 2009 Jul;76(1):81-8. Epub 2009 Mar 18. [12] Shlipak MG, Coca SG, Wang Z, Devarajan P, Koyner JL, Patel UD, Thiessen-Philbrook H, Garg AX, Parikh CR; TRIBE-AKI Consortium.Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery. Am J Kidney Dis. 2011 Sep;58(3):366-73. Epub 2011 May 20. [13] Targo?ska-Stepniak B, Majdan M.Cystatin C concentration is correlated with disease activity in rheumatoid arthritis patients. Scand J Rheumatol. 2011;40(5):341-6. Epub 2011 May 30. [14] Shlipak MG, Katz R, Sarnak MJ, Fried LF, Newman AB, Stehman-Breen C, Seliger SL, Kestenbaum B, Psaty B, Tracy RP, Siscovick DS.Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med. 2006 Aug 15;145(4):237-46. [15] Delanaye P, Cavalier E, Radermecker RP, Paquot N, Depas G, Chapelle JP, Scheen AJ, Krzesinski JM.Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa. Nephron Clin Pract. 2008;110(3):c158-63. Epub 2008 Oct 27. [16] López Gómez JM, Sacristán Enciso B, Micó M, Arias Meneses F, de Sande Medel F, Alejo S.Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages a. Nefrologia. 2011;31(5):560-6. doi: 10.3265/Nefrologia.pre2011.Jul.10834. [17] Warwas M, Piwowar A.Urinary cystatin C as a biomarker of renal tubular injury. Postepy Hig Med Dosw (Online). 2011 Sep 2;65:562-8. [18] Reznichenko NE, Panphilova EIu, Evdokimova MA, Osmolovskaia VS, Chumakova OS, Dankovtseva EN, Baklanova TN, Barinov VG, Sidorenko BA, Zateĭshchikov DA.Cystatin C level is independently related to risk of unfavorable outcome after acute coronary syndrome in individuals with normal or moderately reduced renal function. Kardiologiia. 2011;51(6):4-10. [19] Bleher O, Ehni M, Gauglitz G.Label-free quantification of cystatin C as an improved marker for renal failure. Anal Bioanal Chem. 2011 Aug 20. [20] Ito H, Pacold IV, Durazo-Arvizu R, Liu K, Shilipak MG, Goff DC Jr, Tracy RP, Kramer H.The effect of including cystatin C or creatinine in a cardiovascular risk model for asymptomatic individuals: the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2011 Oct 15;174(8):949-57. Epub 2011 Aug 30.
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